Before I get into the review: It should be noted here that when the Doctor goes into the reverse timestream it can be difficult to read, unless you've familiar with unflipped manga. It took me a while to realize there's a visual cue. In the TV series, Russel T. Davis has it set up where the "tint" of the vortex the TARDIS travels through depends on whether your moving forward (redish) or backwards (blueish) in time. In the normal white space, this is reflected to make it easier to the reader. When the space around the panels is blue, you need to go to the end of the "blue sequence" and read your way back to the "red sequence". Once you figure this out, it makes the comic easier to read.
What they got right: With that information in mind, what you have is an interesting, if not STILL confusing, story. The point of view makes sense, even if the biology doesn't. The alien designs are well done, and takes advantage of the comic medium, as these designs would be hard to pull of on TV, even with a lot of CG. (And imagine the strain on David Tennant's acting skills, as he would have nobody to really play against.)
What they got wrong: An explanation of the visual cue beyond "parts of this comic may read better backwards rather than forwards" might have been helpful. Usually, the "white space" is ignored in favor of the panels, where the story is. It's innovative to use that space, but I didn't pick up on it at first and I'm betting I'm not the only one. The fact that the art (outside of the alien designs) don't really stand out may actually be a good thing, so maybe I'm putting this in the wrong section. After all, you have enough on your mind following the story. However, there's one panel that looks like the Doctor's eyes are going to shoot out of his head.
Recommendation: You'd best be in the right frame of mind to follow this book. Rich Johnson gets points for even trying this, and bonus points for succeeding in it. It's like taking that ball of "wibbly wobbly timey-whimey…stuff" the Doctor is always talking about lately, stuffing in one of those "will it blend" blenders you see on the internet, and indeed blending it nicely. If you like something different, go for it.